SAB2502028

Anti-SLC6A4 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonym(s): 5-HTT, 5-HTTLPR, 5HTT, HTT, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: goat
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, bovine, human, mouse
• technique(s): ELISA: suitable; flow cytometry: suitable; immunofluorescence: suitable
• UniProt accession no.: P31645
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SLC6A4(6532)

Description

General description

Solute carrier family 6 member 4 (SLC6A4) is also known as 5-hydroxytryptamine transporter (5-HTT). It is an integral membrane protein, which is mapped to human chromosome 17q11.2. The encoded protein is a member of the SLC6 (solute carrier family 6) gene family and is mainly expressed in brain and blood cells.

Immunogen

Peptide with sequence C-KERIIKSITPETPT, from the C-terminal region of the protein sequence according to NP_001036.1

Biochem/physiol Actions

Solute carrier family 6 member 4 (SLC6A4) catalyzes the transport of neurotransmitter serotonin from the synaptic space into presynaptic neurons. It plays a vital role in mood and anxiety regulation. Mutation in the gene may alter the expression of serotonin (5HT) in the synaptic cleft, which ultimately leads to schizophrenia. Allelic variations in the gene increase the risk of susceptibility to autism and rigid-compulsive behaviors.

Features and Benefits

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Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable