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Key Documents

PLA0251

Sigma-Aldrich

Rabbit anti-MEKK1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

E3 ubiquitin protein ligase, MAP/ERK kinase kinase 1, MAPK/ERK kinase kinase 1, MAPKKK1, MEK kinase 1, MEKK, MEKK 1, MEKK1, SRXY6, mitogen-activated protein kinase kinase kinase 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

technique(s)

immunoprecipitation (IP): 5- 10 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_005912.1

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

rabbit ... MEKK1(4214)

Immunogen

The epitope recognized by PLA0251 maps to a region between residue 50 and 100 of human MAP/ERK kinase kinase 1 using the numbering given in entry NP_005912.1 (GeneID 4214).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

MEK (MAPK/ERK kinase) kinase 1 (MEKK1) is encoded by the MAP3K1 (mitogen-activated protein kinase kinase kinase 1) gene. MEKK1 is a component of a protein kinase signal transduction cascade that activates the ERK and JNK kinase pathways by phosphorylation of MEK1 (MAP2K1) and MEK4 (MAP2K4). MEKK1 activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13233].

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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International journal of oncology, 45(2), 675-682 (2014-05-29)
Nutlin-3 which occupies the p53 binding pocket in HDM2, has been reported to activate apoptosis through both the transcriptional activity-dependent and -independent programs of p53. Transcription-independent apoptosis by nutlin-3 is triggered by p53 which is translocated to mitochondria. However, we

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