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P8891

Propantheline bromide

Name: Propantheline bromide
Brand: SIGMA

≥97% (TLC), powder

Synonym(s):

(2-Hydroxyethyl)diisopropylmethylammonium bromide xanthene-9-carboxylate

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About This Item

Linear Formula:

C₂₃H₃₀NO₃Br

CAS Number:

50-34-0

Molecular Weight:

448.39

EC Number:

200-030-6

MDL number:

MFCD00050291

UNSPSC Code:

12352111

PubChem Substance ID:

24278660

NACRES:

NA.77

Assay

≥97% (TLC)

form

powder

color

white to off-white

solubility

H₂O: 50 mg/mL

originator

Shire

SMILES string

[Br-].CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc3ccccc13)C(C)C

InChI

1S/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H/q+1;/p-1

InChI key

XLBIBBZXLMYSFF-UHFFFAOYSA-M

Gene Information

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

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Biochem/physiol Actions

Inhibits action of acetylcholine at post-ganglionic synapses; muscarinic acetylcholine receptor antagonist; antispasmodic; reduces gastric acid secretion.

Features and Benefits

This compound was developed by Shire. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Inhibition of nicotine-induced relaxation of the bovine retractor penis muscle by compounds known to have ganglion-blocking properties.

S Alaranta et al.

British journal of pharmacology, 101(2), 472-476 (1990-10-01)

1. The relative potency in blocking the nicotine-induced relaxation of the bovine retractor penis muscle (BRP) was estimated for 12 drugs known to have ganglion-blocking properties. 2. The order of potency of the drugs studied was mecamylamine greater than chlorisondamine

Classification of the presynaptic muscarinic receptor subtype that regulates 3H-acetylcholine secretion in the guinea pig urinary bladder in vitro.

P Alberts

The Journal of pharmacology and experimental therapeutics, 274(1), 458-468 (1995-07-01)

The experiments were done to investigate the presence and subtype of functionally presynaptic muscarinic receptors in cholinergic nerves of the guinea pig urinary bladder. Bladder strips were incubated with 3H-choline and superfused with Tyrode's solution containing eserine. Secreted 3H-acetylcholine was

Transcriptome profiling of granulosa and theca cells during dominant follicle development in the horse.

F Xavier Donadeu et al.

Biology of reproduction, 91(5), 111-111 (2014-09-26)

Several aspects of equine ovarian physiology are unique among domestic species. Moreover, follicular growth patterns are very similar between horses and humans. This study aimed to characterize, for the first time, global gene expression profiles associated with growth and preovulatory

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