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P4997

Sigma-Aldrich

Anti-Potassium Channel KCa3.1 (Intermediate-conductance Ca2+-activated Potassium Channel 4) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-IKCa1, Anti-KCNN4, Anti-SK4

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About This Item

MDL number:
MFCD06798513
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human, rat, mouse (predicted)

technique(s)

western blot: 1:200

UniProt accession no.

O15554

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCNN4(3783)
mouse ... Kcnn4(16534)
rat ... Kcnn4(65206)

Immunogen

synthetic peptide corresponding to amino acid residues 350-363 of rat KCa3.1. The sequence has 100% homology with human, mouse, and pig.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Western Blotting (1 paper)

Physical form

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Spatial separation of endothelial small-and intermediate-conductance calcium-activated potassium channels (KCa) and connexins: possible relationship to vasodilator function?
Sandow SL et al
Journal of Anatomy, 209.5, 689-698 (2006)
Characteristics of Kcnn4 channels in the apical membranes of an intestinal epithelial cell line.
Basalingappa KMet al
American Journal of Physiology: Gastrointestinal and Liver Physiology, 301(5), G905-G911 (2011)
Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice.
Reich EP et al
European Journal of Immunology, 35(4), 1027-1036 (2005)
Phosphatidylserine exposure and calcium-activated potassium efflux in platelets.
Danièle Kerbiriou-Nabias et al.
British journal of haematology, 155(2), 268-270 (2011-04-13)
The Ca2+-activated K+ channel KCNN4/KCa3.1 contributes to microglia activation and nitric oxide-depenThe Ca2+-activated K+ channel KCNN4/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration.dent neurodegeneration.
Kaushal V et al
The Journal of Neuroscience, 27(1), 234-244 (2007)
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