J4144
Jo-1 human
recombinant, expressed in E. coli, solution
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recombinant
expressed in E. coli
Quality Level
form
solution
mol wt
55 kDa by SDS-PAGE
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... HARS(3035)
General description
Jo-1, or histidyl-transfer ribonucleic acid synthetase, is a homodimeric enzyme that catalyzes the coupling of histidine to its specific transfer RNA (tRNA), prior to transport of histidine to the ribosome, and subsequent incorporation of histidine into polypeptide chains. Jo-1 has been associated with various autoimmune disorders, such as polymyositis and dermatomyositis, and T-cell mediated autoimmunity.
Biochem/physiol Actions
The anti-Jo-1 antibody has been associated with an increased frequency of interstitial pulmonary disease in polymyositis/dermatomyositis patients.
Used in the immunoassay for antibodies to Jo-1.
Physical form
Solution in 6 M urea, 500 mM sodium chloride, 10 mM Tris HCl buffer, pH 8.0.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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M Nishikai et al.
British journal of rheumatology, 37(4), 357-361 (1998-06-10)
We evaluated an enzyme-linked immunosorbent assay (ELISA) for detecting anti-Jo-1 antibodies in patients with polymyositis (PM) or dermatomyositis (DM) by use of the recombinant fusion protein Jo-1. Sera from 64 patients with PM or DM, from 80 patients with other
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