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H6904

Sigma-Aldrich

6β-Hydroxycortisol

≥98%

Synonym(s):

4-Pregnene-6,11β,17,21-tetrol-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C21H30O6
CAS Number:
3078-34-0
Molecular Weight:
378.46
MDL number:
MFCD00200405
UNSPSC Code:
12352200
PubChem Substance ID:
24895777
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

Assay

≥98%

form

powder

technique(s)

HPLC: suitable

solubility

methanol: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

CC12CCC(=O)C=C1C(O)CC3C4CC[C@](O)(C(=O)CO)C4(C)CC(O)C23

InChI

1S/C21H30O6/c1-19-5-3-11(23)7-14(19)15(24)8-12-13-4-6-21(27,17(26)10-22)20(13,2)9-16(25)18(12)19/h7,12-13,15-16,18,22,24-25,27H,3-6,8-10H2,1-2H3/t12?,13?,15?,16?,18?,19?,20?,21-/m0/s1

InChI key

GNFTWPCIRXSCQF-JFQOUMBGSA-N

Application

6β-Hydroxycortisol has been used in liquid chromatography with tandem mass spectrometry (LC/MS/MS) analysis to confirm the human embryonic kidney (HEK293) cell-based conversion of parent cortisol to 6β-hydroxycortisol (6βOH) metabolites.

Biochem/physiol Actions

6β-Hydroxycortisol serves as a substrate for the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins (MATE1 and MATE-2K).
6β-Hydroxycortisol is a metabolite of cortisol.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yuichiro Imamura et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(4), 685-694 (2014-02-04)
6β-Hydroxycortisol (6β-OHF) is a substrate of the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-transfected cells. This study aimed to examine the contribution of OAT3 and MATEs to the
Kevin A Lidberg et al.
Scientific reports, 11(1), 4722-4722 (2021-02-27)
CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders. Pharmacogenetic studies have reported inconsistent linkages between CYP3A5 expression and hypertension, however, most investigators have

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