B4063

BIMU8 hydrate

≥98% (HPLC)

• Synonym(s): 2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide Hydrochloride (1:1) hydrate
• Empirical Formula (Hill Notation): C₁₉H₂₆N₄O₂·HCl · xH₂O
• CAS Number: 134296-40-5
• Molecular Weight: 378.90 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329773228
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: off-white to light tan
• solubility: H₂O: ≥5 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C19H26N4O2.ClH.H2O/c1-12(2)22-16-6-4-5-7-17(16)23(19(22)25)18(24)20-13-10-14-8-9-15(11-13)21(14)3;;/h4-7,12-15H,8-11H2,1-3H3,(H,20,24);1H;1H2/t13-,14+,15-;;
• InChI key: HZJJVFOOACXPTH-XZAJHMFNSA-N

Description

Biochem/physiol Actions

BIMU8 hydrate is a potent 5-HT₄ serotonin receptor agonist. Serotonin (5-HT) is a major neurotransmitter that acts through a family of GPCRs and one ion channel. 5-HT₄ receptor is GPCR expressed in many tissues, including brain, and modulates dopamine secretion, learning, and memory. BIMU8 is a full agonist at 5-HT₄, but it binds differently than the endogenous ligand, 5-HT, shown through site-directed mutagenesis studies. It depolarizes neurons and was used to localize 5-HT₄ to somatic but not dendritic regions of CA1 pyramidal neurons.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable