A263
ATPA
solid
Synonym(s):
(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C10H16N2O4
CAS Number:
Molecular Weight:
228.25
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
form
solid
Quality Level
color
white
solubility
DMSO: 10 mg/mL
H2O: 2.5 mg/mL
SMILES string
CC(C)(C)c1onc(O)c1CC(N)C(O)=O
InChI
1S/C10H16N2O4/c1-10(2,3)7-5(8(13)12-16-7)4-6(11)9(14)15/h6H,4,11H2,1-3H3,(H,12,13)(H,14,15)
InChI key
PIXJURSCCVBKRF-UHFFFAOYSA-N
Gene Information
human ... GRIK1(2897)
rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409)
Biochem/physiol Actions
Selective kainate receptor agonist.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Jon Valgeirsson et al.
Journal of medicinal chemistry, 46(26), 5834-5843 (2003-12-12)
A series of 2-arylureidobenzoic acids (AUBAs) was prepared by a short and effective synthesis, and the pharmacological activity at glutamate receptors was evaluated in vitro and in vivo. The compounds showed noncompetitive antagonistic activity at the kainate receptor subtype GluR5.
Alexander Jack et al.
Molecular neurobiology, 56(7), 4960-4979 (2018-11-14)
During neuronal development, AMPA receptors (AMPARs) and NMDA receptors (NMDARs) are important for neuronal differentiation. Kainate receptors (KARs) are closely related to AMPARs and involved in the regulation of cortical network activity. However, their role for neurite growth and differentiation
Nicola Micale et al.
Journal of medicinal chemistry, 45(20), 4433-4442 (2002-09-20)
In this paper we describe the synthesis of a series of novel 2-[(4-alkylsemicarbazono)-(4-aminophenyl)-methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters (10-19) carrying an alkylsemicarbazono moiety at a benzylic site. The influence of this group on the biological activity was evaluated by testing the corresponding
James S Robinson et al.
American journal of physiology. Heart and circulatory physiology, 282(6), H2371-H2376 (2002-05-11)
The hypothesis that glutamate dilates pial arterioles of newborn pigs through the production of carbon monoxide (CO) was addressed. Anesthesized newborn pigs were equipped with cranial windows to measure pial arteriolar responses to stimuli. Heme oxygenase (HO) inhibitors added topically
Marie-Louise Lunn et al.
Journal of medicinal chemistry, 46(5), 872-875 (2003-02-21)
Two X-ray structures of the GluR2 ligand-binding core in complex with (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid ((S)-ATPA) have been determined with and without Zn(2+) ions. (S)-ATPA induces a domain closure of ca. 21 degrees compared to the apo form. The tert-butyl moiety of
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service