Skip to Content
Merck
All Photos(1)

Key Documents

More Documents

A2351

Sigma-Aldrich

Anti-ADAM-8, Propeptide Domain antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-A Disintegrin And Metalloproteinase-8, Anti-CD156, Anti-MS2

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

MDL number:
MFCD04040160
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

rat, human, pig

concentration

~1 mg/mL

technique(s)

western blot: 1:1,000

UniProt accession no.

P78325

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADAM8(101)
pig ... ADAM8(100156146)
rat ... Tubgcp2(309098)

General description

ADAM8, a transmembrane glycoprotein, also known as MS2 and CD156, is a member of the metalloproteinase family containing disintegrin-like domains (ADAMs). ADAM8 is up-regulated in the central nervous system following neurogeneration and activation of glia, astrocytes, and microglia, suggesting that it may have a role in neuron-glia interactions. ADAM8 stimulates osteoclasts, suggesting a role in cell adhesion and cell fusion.
Anti-ADAM-8, propeptide domain antibody localizes human, porcine, and rat ADAM8 and does not react with other ADAMs. In immunoblotting assays against the reduced protein, the antibody recognizes 52kDa and 70kDa bands in conditioned media or cell lysates. In culture media, the 52kDa form is predominant.

Immunogen

synthetic peptide corresponding to the propeptide domain of human ADAM-8.

Application

Anti-ADAM-8, propeptide domain antibody can be used for western blotting assays at a dilution of 1:1,000.

Physical form

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Uwe Schlomann et al.
The Journal of biological chemistry, 277(50), 48210-48219 (2002-10-10)
ADAMs (a disintegrin and metalloprotease domains) are metalloprotease and disintegrin domain-containing transmembrane glycoproteins with proteolytic, cell adhesion, cell fusion, and cell signaling properties. ADAM8 was originally cloned from monocytic cells, and its distinct expression pattern indicates possible roles in both
S J Choi et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 16(5), 814-822 (2001-05-09)
We used polymerase chain reaction (PCR)-selective complementary DNA (cDNA) subtraction hybridization with an immortalized murine osteoclast (OCL) precursor cell line to identify genes that are highly expressed in OCLs compared with OCL precursors and which may be involved in the
S Yoshida et al.
International immunology, 2(6), 585-591 (1990-01-01)
cDNA clones which strongly hybridized with a 3.1 kb mRNA from mouse macrophages and macrophage cell lines and weakly with mRNA from P815 but not from a variety of other cell lines and tissues were isolated from cDNA libraries constructed
U Schlomann et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(21), 7964-7971 (2000-10-26)
ADAM proteases, defined by extracellular disintegrin and metalloprotease domains, are involved in protein processing and cell-cell interactions. Using wobbler (WR) mutant mice, we investigated the role of ADAMs in neurodegeneration and reactive glia activation in the CNS. We found that

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service