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Key Documents

44213

Sigma-Aldrich

Thromboplastin from rabbit

Synonym(s):

Thromboplastin, Factor III, Thrombokinase

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

rabbit

Quality Level

form

lyophilized solid

UniProt accession no.

storage temp.

2-8°C

Gene Information

rabbit ... F3(100009127)

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Application

Thromboplastin from rabbit has been used:
  • as a standard in tissue factor procoagulant activity assay (TF-PCA)
  • in pulmonary embolism assay
  • as a positive control in clotting assay using human plasma

Biochem/physiol Actions

Thromboplastin (Tissue factor) is a transmembrane protein, the chief in vivo activator of blood coagulation that leads to thrombin generation and fibrin deposition. It is also important in the activation of the coagulation protease cascade and is involved in the lethality of sepsis.,
Thromboplastin from rabbit might be used to produce disseminated intravascular coagulation (DIC) in animal models.

Packaging

One vial contains 3-4 mg thromboplastin.

Reconstitution

Reconstitute the content of 1 vial in 4 ml 10 mm CaCl2

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Resp. Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M E Bromberg et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(18), 8205-8209 (1995-08-29)
Several studies have established a link between blood coagulation and cancer, and more specifically between tissue factor (TF), a transmembrane protein involved in initiating blood coagulation, and tumor metastasis. In the study reported here, a murine model of human melanoma
J Erlich et al.
Infection and immunity, 67(5), 2540-2546 (1999-05-04)
Tissue factor (TF) is the major activator of the coagulation protease cascade and contributes to lethality in sepsis. Despite several studies analyzing TF expression in animal models of endotoxemia, there remains debate about the cell types that are induced to
Nan Zhang et al.
The Journal of experimental medicine, 216(6), 1291-1300 (2019-05-03)
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in
Richard Beatson et al.
Communications biology, 3(1), 644-644 (2020-11-06)
The tumour microenvironment plays a crucial role in the growth and progression of cancer, and the presence of tumour-associated macrophages (TAMs) is associated with poor prognosis. Recent studies have demonstrated that TAMs display transcriptomic, phenotypic, functional and geographical diversity. Here

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