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44001

Sigma-Aldrich

N-Acetyl-D-glucosamine 6-sulfate sodium salt

≥98.0% (TLC)

Synonym(s):

GlcNAc-6S

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About This Item

Linear Formula:
C8H14NO9SNa
CAS Number:
108321-79-5
Molecular Weight:
323.25
MDL number:
MFCD00063415
UNSPSC Code:
12352201
PubChem Substance ID:
329756440
NACRES:
NA.25

biological source

synthetic

Quality Level

100

description

Mixed anomers

Assay

≥98.0% (TLC)

form

solid

optical activity

[α]20/D 32.0±2.0, c = 0.1% (w/v) in water

technique(s)

thin layer chromatography (TLC): suitable

color

colorless

storage temp.

−20°C

SMILES string

[Na+].CC(=O)N[C@H]1C(O)O[C@H](COS([O-])(=O)=O)[C@@H](O)[C@@H]1O

InChI

1S/C8H15NO9S.Na/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16;/h4-8,11-13H,2H2,1H3,(H,9,10)(H,14,15,16);/q;+1/p-1/t4-,5-,6-,7-,8?;/m1./s1

InChI key

CBUJZKTVEFVBBG-FROKLYQUSA-M

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Application

N-Acetyl-D-glucosamine 6-sulfate (GlcNAc-6S) is used as a substrate and inhibitor to identify, differentiate and characterize various sulfatase(s), especially N-acetylglucosamine-6-sulphatase(s).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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N H Elçioglu et al.
Genetic counseling (Geneva, Switzerland), 20(2), 133-139 (2009-08-05)
A novel loss-of-function mutation in the GNS gene causes Sanfilippo syndrome type D: Mucopolysaccharidosis type IIID (MIM 252940) is the least common form of the four subtypes of Sanfilippo syndrome. It is an autosomal recessive lysosomal disorder caused by a
Shengyuan Xu et al.
The Biochemical journal, 387(Pt 3), 841-847 (2004-12-15)
A 75 kDa protein was purified to homogeneity from granule extracts of normal human granulocytes using Sephadex G-75 chromatography, Mono-S cation exchange chromatography and chromatofocusing. The protein consisted of one chain with a molecular mass of 75 kDa, as determined
Andrew J Nok et al.
Journal of biochemical and molecular toxicology, 17(1), 59-66 (2003-03-05)
The venom of Naja nigricolis was found to contain a high level of the enzyme aryl sulfatase. The enzyme was isolated from the venom of N. nigriclois and purified to electrophoretic homogeneity by gel chromatography on Sephadex G-100, DEAE-cellulose, and
Andrea Mok et al.
Genomics, 81(1), 1-5 (2003-02-08)
Mucopolysaccharidosis type IIID (MPS IIID; Sanfilippo syndrome type D; MIM 252940) is caused by deficiency of the activity of N-acetylglucosamine-6-sulfatase (GNS), which is normally required for degradation of heparan sulfate. The clinical features of MPS IIID include progressive neurodegeneration, with

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