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17929

Sigma-Aldrich

O-Methyl-O′-succinylpolyethylene glycol 5′000

Synonym(s):

Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 5′000, Polyethylene glycol 5000 monomethyl ether succinate

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About This Item

Linear Formula:
CH3O(CH2CH2O)nCOCH2CH2COOH
CAS Number:
31961-02-1
MDL number:
MFCD00284260
UNSPSC Code:
51171641
NACRES:
NA.26

form

powder

Quality Level

100

mol wt

Mr ~5100

mp

56-60 °C

Ω-end

carboxylic acid

α-end

methoxy

storage temp.

−20°C

Application

Polyethylene glycol 5000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.
Soluble polymer for solid phase synthesis of imines and β-lactams; attaching peptides to PEG

Biochem/physiol Actions

O-Methyl-O′-succinylpolyethylene glycol 5′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
063737/2

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A Bogdanov et al.
Journal of drug targeting, 4(5), 321-330 (1997-01-01)
A co-polymer of O-methyl polyethylene(glycol)-O'-succinate (MPEGs, m.w. 5100) and poly-l-lysine (PL, median m.w. 32700, degree of polymerization 256) has been synthesized by covalent grafting. The resultant MPEGs-PL (30% modification degree of epsilon-amino groups) had a hydrodynamic diameter corresponding to a
V. Molteni et al.
Tetrahedron Letters, 39, 1257-1257 (1998)
M. Joppich, P.L. Luisi
Makromol. Chem., 180, 1381-1381 (1979)
Enhanced stability of PEG-block-poly(N-hexyl stearate l-aspartamide) micelles in the presence of serum proteins.
Diezi TA, Bae Y, Kwon GS.
Molecular Pharmacology, 7, 1355-1360 (2010)
Peptide/protein-polymer conjugates: synthetic strategies and design concepts.
Gauthier MA, Klok HA.
Chemical Communications (Cambridge, England), 21, 2591-2611 (2008)
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