HMMP2MAG-55K
MILLIPLEX® Human MMP Magnetic Bead Panel 2 - Immunology Multiplex Assay
Matrix Metalloproteinase Bead-Based Multiplex Assays using the Luminex technology enable the simultaneous analysis of multiple MMPs biomarkers in human serum, plasma and cell culture samples.
Synonym(s):
Human matrix metalloproteinase multiplex kit, Luminex® Human MMP immunoassay, Millipore human MMP panel
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About This Item
UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84
Recommended Products
Quality Level
species reactivity
human
manufacturer/tradename
Milliplex®
assay range
accuracy: 72-98%
standard curve range: 14-10,000 pg/mL
(MMP-9)
standard curve range: 27-20,000 pg/mL
(MMP-1)
standard curve range: 27-20,000 pg/mL
(MMP-10)
standard curve range: 548-400,000 pg/mL
(MMP-7)
standard curve range: 68-50,000 pg/mL
(MMP-2)
technique(s)
multiplexing: suitable
detection method
fluorometric (Luminex xMAP)
shipped in
wet ice
General description
MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs′ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines, and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in arthritis, cardiovascular disease and tumor growth and metastasis.
MMP/TIMP research plays a significant role in achieving a deeper understanding of disease states such as chronic inflammation, cardiovascular disease, and cancer.
The MILLIPLEX® Human MMP Bead Panel 2 (MMP-1, -2, -7, -9, -10) will enable you to explore the modulation of and the function of MMP expression in multiple therapeutic areas.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Cytokines/Chemokines
MMP/TIMP research plays a significant role in achieving a deeper understanding of disease states such as chronic inflammation, cardiovascular disease, and cancer.
The MILLIPLEX® Human MMP Bead Panel 2 (MMP-1, -2, -7, -9, -10) will enable you to explore the modulation of and the function of MMP expression in multiple therapeutic areas.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Cytokines/Chemokines
Specificity
Cross Reactivty
No significant cross-reactivity was observed among analytes in this panel.
No significant cross-reactivity was observed among analytes in this panel.
Application
- Analytes: MMP-1, MMP-2, MMP-7, MMP-9, MMP-10
- Recommended Sample type: human serum, plasma, tissue/cell lystate and culture supernatant samples
- Recommended Sample dilution: 1:20
- Assay Run Time: One day
- Research Category: Inflammation & Immunology
Features and Benefits
Design your multiplex kit by choosing available analytes within this panel.
Storage and Stability
Recommended storage for kit components is 2 - 8°C.
Other Notes
Sensitivity: See protocol for sensitivities of individual analytes.
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
Target Organs
Respiratory Tract
Storage Class Code
10 - Combustible liquids
Certificates of Analysis (COA)
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Livia V Souza et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 30(1), 60-70 (2019-11-23)
The purpose of this study was to investigate whether an intervention with physical activity (PA) would promote positive effects on the angiogenic factors, mobilization, and functionality of circulating endothelial progenitor cells (EPCs) in children with low birth weight (LBW). Thirty-five
Ulrike Müller et al.
Mediators of inflammation, 2015, 626530-626530 (2015-07-18)
In cystic fibrosis (CF) the upper (UAW) and lower airways (LAW) are reservoirs for pathogens like Pseudomonas aeruginosa. The consecutive hosts' release of proteolytic enzymes contributes to inflammation and progressive pulmonary destruction. Objectives were to assess dynamics of protease :
Larissa Berloffa Belardin et al.
Scientific reports, 9(1), 903-903 (2019-01-31)
Matrix Metalloproteinases (MMPs) and their regulators - Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) - participate in extracellular matrix remodeling, fibrosis, and semen liquefaction, as well as to inflammatory activity. Seminal plasma has been shown to contain MMPs (MMP-2 and MMP-9)
M R Milone et al.
Cell death & disease, 4, e641-e641 (2013-05-25)
The nitrogen-containing bisphosphonates (N-BP) zoledronic acid (ZOL) inhibits osteoclast-mediated bone resorption, and it is used to prevent skeletal complications from bone metastases. ZOL has also demonstrated anticancer activities in preclinical models and, recently, in cancer patients, highlighting the interest in
Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury.
Karolina Minta et al.
Scientific reports, 10(1), 18075-18075 (2020-10-24)
Matrix metalloproteinases (MMPs) are extracellular enzymes involved in the degradation of extracellular matrix (ECM) proteins. Increased expression of MMPs have been described in traumatic brain injury (TBI) and may contribute to additional tissue injury and blood-brain barrier damage. The objectives
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