1.07185
Pepsin
(from porcine gastric mucosa) 0.7 FIP-U/mg for biochemistry EC 3.4.23.1
Synonym(s):
Pepsin
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About This Item
CAS Number:
Molecular Weight:
35000
MDL number:
UNSPSC Code:
12352204
EC Index Number:
232-629-3
NACRES:
NA.21
pH
4.0-5.0 (20 °C, 10 g/L in H2O)
solubility
10 g/L
bulk density
380‑420 kg/m3
storage temp.
2-30°C
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Application
Pepsin has been used in the preparation of simulated gastric fluid to perform in vitro gastric digestion.
Biochem/physiol Actions
Pepsin is a component of gastric juice and is associated with protein digestion. It is an endopeptidase that catalyzes the degradation of proteins into peptides and amino acids for small intestinal absorption. Pepsin is released as a zymogen (pepsinogen) by the chief cells of the gastric lining. It gets activated by the acidic environment created by the hydrochloric acid (HCl) of gastric juice. Pepsin is active at pH 1.5 to 2, in the stomach. It is involved in the conversion of food bolus into chyme. It is associated with laryngopharyngeal reflux (LPR) indicated by chronic cough, mild dysphagia, hoarseness, and non-productive throat clearing.
Analysis Note
Appearance: fine, slightly yellow powder
Activity/FIP (Hemoglobin; pH 1.6; 25 °C): ≥ 0.70 FIP-U/mg
pH-value (1 %; water): 4.0 - 5.0
Water (according to Karl Fischer): ≤ 6.0 %
Activity/FIP (Hemoglobin; pH 1.6; 25 °C): ≥ 0.70 FIP-U/mg
pH-value (1 %; water): 4.0 - 5.0
Water (according to Karl Fischer): ≤ 6.0 %
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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