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biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... CFLAR(8837)
Specificity
long form of FLIP
Immunogen
peptide corresponding to amino acids 447-464 [NGYMYDWNSRVSAKEKYY] of human FLIP
Application
Detect FLIP using this Anti-FLIP Antibody, CT validated for use in WB.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Quality
routinely evaluated by immunoblot on Jurkat, A431, Raji, 3T3, CTLL, PC12 or L6 RIPA cell lysates
Target description
55kDa
Physical form
Format: Purified
PBS, pH 7.4, 0.02% sodium azide before the addition of glycerol to 30%
Protein A chromatography
Storage and Stability
2 years at -20°C
Analysis Note
Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Predisposition to apoptosis in keratin 8-null liver is related to inactivation of NF-?B and SAPKs but not decreased c-Flip.
Lee, J; Jang, KH; Kim, H; Lim, Y; Kim, S; Yoon, HN; Chung, IK; Roth, J; Ku, NO
Biology Open null
F-box protein 10, an NF-?B-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway.
Ge, R; Wang, Z; Zeng, Q; Xu, X; Olumi, AF
Cell Death and Differentiation null
Antibody validation by combining immunohistochemistry and protein extraction from formalin-fixed paraffin-embedded tissues.
Claudia Schuster,Katharina Malinowsky,Sibylle Liebmann,Daniela Berg,Claudia Wolff et al.
Histopathology null
Phosphatidylinositol 3-kinase/Akt signaling mediates interleukin-6 protection against p53-induced apoptosis in M1 myeloid leukemic cells.
Vesely, DL; Hoffman, B; Liebermann, DA
Oncogene null
Rongbin Ge et al.
Oncotarget, 6(30), 28973-28987 (2015-09-12)
Metformin has emerged as a potential anticancer agent. Here, we demonstrate that metformin plays an anti-tumor role via repressing N-cadherin, independent of AMPK, in wild-type N-cadherin cancer cells. Ectopic-expression of N-cadherin develops metformin-resistant cancer cells, while suppression of N-cadherin sensitizes
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