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999993P

Avanti

14:0 Diether PC

Avanti Polar Lipids 999993P, powder

Synonym(s):

1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C36H76NO6P
CAS Number:
36314-48-4
Molecular Weight:
649.97
UNSPSC Code:
51191904
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 10 mg (999993P-10mg)
pkg of 1 × 25 mg (999993P-25mg)

manufacturer/tradename

Avanti Polar Lipids 999993P

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OCCCCCCCCCCCCCC)COCCCCCCCCCCCCCC)=O

General description

14:0 Diether PC (phosphocholine) is a glycerophospholipid having choline as the alcohol moiety, attached to the phosphate group. It has two tetradecyl chains attached to the sn-1 and sn-2 positions of the glycerol backbone by ether bonds.

Application

14:0 Diether PC or 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine might be used:
  • to prepare bicelle samples for solid-state NMR experiment
  • to compose isotropically tumbling small bicelles, to study its size and morphology
  • in lipid bicelles to reconstitute EmrE (secondary active transport protein)

Packaging

5 mL Amber Glass Screw Cap Vial (999993P-10mg)
5 mL Amber Glass Screw Cap Vial (999993P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Expression and purification of the membrane protein p7 from hepatitis C virus
Cook GA, et al.
Pept. Sci., 96(1), 32-40 (2011)
Assessing interactions between a polytopic membrane protein and lipid bilayers using differential scanning calorimetry and solid-state NMR
Banigan JR, et al.
The Journal of Physical Chemistry B, 122(8), 2314-2322 (2018)
Assessing the size, stability, and utility of isotropically tumbling bicelle systems for structural biology
Wu H, et al.
Biochimica et Biophysica Acta - Biomembranes, 1798(3), 482-488 (2010)
H A Pérez et al.
Langmuir : the ACS journal of surfaces and colloids, 36(10), 2644-2653 (2020-02-20)
The lack of carbonyl groups and the presence of ether bonds give the lipid interphase a different water organization around the phosphate groups that affects the compressibility and electrical properties of lipid membranes. Generalized polarization of 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine (14:0 diether PC)
Jadegoud Yaligar et al.
PloS one, 9(3), e91436-e91436 (2014-03-19)
Dietary saturated fatty acids contribute to the development of fatty liver and have pathogenic link to systemic inflammation. We investigated the effects of dietary fat towards the pathogenesis of non-alcoholic fatty liver disease by longitudinal in vivo magnetic resonance spectroscopy

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