890808P

22:0 Trehalose

Avanti Research^™ - A Croda Brand

• Synonym(s): D-(+)-trehalose 6,6′-dibehenate
• Empirical Formula (Hill Notation): C₅₆H₁₀₆O₁₃
• CAS Number: 66758-35-8
• Molecular Weight: 987.43
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• form: powder
• packaging: pkg of 1 × 25 mg (890808P-25mg); pkg of 1 × 5 mg (890808P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• application(s): vaccine development
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O[C@H]([C@@H](COC(CCCCCCCCCCCCCCCCCCCCC)=O)O[C@H](O[C@@H](O[C@@H]([C@H]([C@@H]1O)O)COC(CCCCCCCCCCCCCCCCCCCCC)=O)[C@@H]1O)[C@@H]2O)[C@@H]2O

Description

General description

22:0 Trehalose is a bioactive glycolipid and an analog of mycobacterial cord factor.

Application

22:0 Trehalose has been used as an adjuvant for Chlamydia vaccine. It has also been used as a component in adjuvant DMT (dimethyldioctadecylammonium/monophosphoryl lipid A/trehalose 6,6′-dibehenate (DDA/MPL/TDB)) to prepare DMT liposome adjuvanted CTT3H (polyprotein) vaccine.

Biochem/physiol Actions

Incorporation of trehalose 6,6′-dibehenate (TDB) into cationic liposomes composed of the quaternary ammonium compound dimethyldioctadecylammonium (DDA) produce an adjuvant system which induces a powerful cell-mediated immune response and a strong antibody response, desirable for a high number of disease targets. It acts as an immunomodulator. 22:0 Trehalose is considered less toxic and an efficient vaccine adjuvant for tuberculosis.

Packaging

5 mL Amber Glass Screw Cap Vial (890808P-25mg)

5 mL Amber Glass Screw Cap Vial (890808P-5mg)

Other Notes

For R&D use only. Not for drug, household, or other uses.

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable