Skip to Content
Merck
All Photos(1)

Documents

850188P

Avanti

18:0-20:4 PI(3,4)P2

powder

Synonym(s):

1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′-bisphosphate) (ammonium salt)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C47H94N3O19P3
CAS Number:
2315262-41-8
Molecular Weight:
1098.18
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

99% (TLC)

form

powder

packaging

package of 1 × 100 μg (850188P-100UG)
package of 1 × 500 μg (850188P-500UG)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@@H](OP(O)([O-])=O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

General description

PI(3,4)P2 is a lipid secondary messenger. It is obtained from the dephosphorylation of PI(3,4,5)P3 by 5-phosphatase.

Biochem/physiol Actions

PI(3,4)P2 plays a role in protein kinase B (PKB) phosphorylation on Ser473 in mast cells. It also binds to certain effectors such as serine/threonine-specific protein kinase (AKT) and dual adaptor of phosphotyrosine and 3-phosphoinositides 1 (DAPP1). It also regulates the activity of actin mesh which is associated with endocytic structures.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850188P-100UG)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850188P-500UG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

PTEN regulates PI (3, 4) P2 signaling downstream of class I PI3K
Malek M, et al.
Molecular Cell, 68(3), 566-580 (2017)
PI (3, 4, 5) P3 and PI (3, 4) P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI (3, 4) P2 levels determine PKB activity
Ma K, et al.
Cellular Signalling, 20(4), 684-694 (2008)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service