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Resomer^® RG 503 H, Poly(D,L-lactide-co-glycolide)

Name: Resomer<SUP>®</SUP> RG 503 H, Poly(<SC>D,L</SC>-lactide-<I>co</I>-glycolide)
Brand: ALDRICH

acid terminated, lactide:glycolide 50:50, M_w 24,000-38,000

Synonym(s):

Poly(D,L-lactide-co-glycolide), PLGA

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About This Item

Linear Formula:

[C₃H₄O₂]_x[C₂H₂O₂]_y

MDL number:

MFCD00131930

UNSPSC Code:

12162002

NACRES:

NA.23

Quality Level

200

form

amorphous

feed ratio

lactide:glycolide 50:50

mol wt

M_w 24,000-38,000

degradation timeframe

<3 months

viscosity

0.32-0.44 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

transition temp

T_g 44-48 °C

storage temp.

2-8°C

SMILES string

OCC(O)=O.CC(O)C(O)=O

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Related Categories

Biomedical Polymers

Application

Controlled release

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Physical form

Biocompatible, biodegradable polymer.

Legal Information

Product of Evonik

RESOMER is a registered trademark of Evonik Rohm GmbH

related product

Product No.

Description

Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Effect of water on exenatide acylation in poly(lactide-co-glycolide) microspheres.

Rongcai Liang et al.

International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)

Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative

Induction of long-lasting protective immunity against Toxoplasma gondii in BALB/c mice by recombinant surface antigen 1 protein encapsulated in poly (lactide-co-glycolide) microparticles.

Shu-Chun Chuang et al.

Parasites & vectors, 6, 34-34 (2013-02-13)

Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or

Development of novel cationic chitosan-and anionic alginate-coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol.

Vanna Sanna et al.

International journal of nanomedicine, 7, 5501-5516 (2012-10-25)

Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may

Isoniazid loaded core shell nanoparticles derived from PLGA-PEG-PLGA tri-block copolymers: in vitro and in vivo drug release.

Mani Gajendiran et al.

Colloids and surfaces. B, Biointerfaces, 104, 107-115 (2013-01-10)

A series of biodegradable low molecular weight PLGA-PEG-PLGA tri-block copolymers have been synthesized in powder form. The anti-tuberculosis drug Isoniazid (INH) loaded polymeric core-shell nanoparticles (CSNPs) have been prepared by sonication followed by water-in-oil-in-water (w/o/w) double emulsification technique. The nanoparticles

Reduced postoperative chronic pain after tension-free inguinal hernia repair using absorbable sutures: a single-blind randomized clinical trial.

Igor Jeroukhimov et al.

Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)

Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures

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