408166
1-(2-Pyridyl)piperazine
≥99%
Synonym(s):
2-Piperazinopyridine
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About This Item
Empirical Formula (Hill Notation):
C9H13N3
CAS Number:
Molecular Weight:
163.22
Beilstein:
140423
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
≥99%
form
liquid
refractive index
n20/D 1.595 (lit.)
bp
120-122 °C/2 mmHg (lit.)
density
1.072 g/mL at 25 °C (lit.)
SMILES string
C1CN(CCN1)c2ccccn2
InChI
1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2
InChI key
GZRKXKUVVPSREJ-UHFFFAOYSA-N
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General description
1-(2-Pyridyl)piperazine is a piperazine derivative.
Application
1-(2-Pyridyl)piperazine may be employed as reagent for the determination of both aliphatic and aromatic isocyanates in air by reversed-phase HPLC., It may be employed as reagent for the fluorometric determination of airborne diisocyantes.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
230.0 °F - closed cup
Flash Point(C)
110 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Determination of trace atmospheric isocyanate concentrations by reversed-phase high-performance liquid chromatography using 1-(2-pyridyl) piperazine reagent.
Goldberg PA, et al.
Journal of Chromatography A, 212(1), 93-104 (1981)
Absorption and fluorescence of 1-(2-pyridyl)-piperazine and four diisocyanate derivatives in solution.
Salthammer T, et al.
Journal of Photochemistry and Photobiology A: Chemistry, 107(1), 159-164 (1997)
Determination of atmospheric isocyanate concentrations by high-performance thin-layer chromatography using 1-(2-pyridyl) piperazine reagent.
Ellwood PA, et al.
Analyst, 106(1258), 85-93 (1981)
Robert Lavieri et al.
Bioorganic & medicinal chemistry letters, 19(8), 2240-2243 (2009-03-21)
This Letter describes the synthesis and structure-activity relationships (SAR) of isoform-selective PLD inhibitors. By virtue of the installation of a 1,3,8-triazaspiro[4,5]decan-4-one privileged structure, PLD inhibitors with nanomolar potency and an unprecedented 40-fold selectivity for PLD2 over PLD1 were developed. Interestingly
P Giral et al.
European journal of pharmacology, 134(1), 113-116 (1987-01-28)
We investigated in mice the effects of one of the principal metabolites of buspirone and gepirone, 1-(2-pyridinyl)-piperazine (1-PmP), on hypothermia and reduced locomotion induced by clonidine (0.25 and 0.06 mg/kg, respectively), tests related to brain alpha-adrenergic function. Both effects were
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