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Sigma-Aldrich

4-Diphenylmethoxy-1-methylpiperidine hydrochloride

95%

Synonym(s):

4-Diphenylmethoxy-1-methylpiperidine, Diphenylpyraline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H23NO · HCl
CAS Number:
132-18-3
Molecular Weight:
317.85
EC Number:
205-049-3
MDL number:
MFCD00012835
UNSPSC Code:
12352100
PubChem Substance ID:
24856946
NACRES:
NA.22

Quality Level

100

Assay

95%

mp

203-205 °C (lit.)

SMILES string

Cl[H].CN1CCC(CC1)OC(c2ccccc2)c3ccccc3

InChI

1S/C19H23NO.ClH/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18-19H,12-15H2,1H3;1H

InChI key

LPRLDRXGWKXRMQ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Related Categories

General description

4-Diphenylmethoxy-1-methylpiperidine hydrochloride is also referred as diphenylpyraline hydrochloride (DPP), is a first-generation antihistamine.

Application

4-Diphenylmethoxy-1-methylpiperidine hydrochloride was used as a pharmacotherapy for Parkinson′s disease.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gennady B Lapa et al.
European journal of pharmacology, 506(3), 237-240 (2005-01-04)
Diphenylpyraline hydrochloride (DPP) is used clinically as an antihistamine drug, but its neurobiological effects are not completely understood. Voltammetry and microdialysis were used to investigate potential actions of DPP on the dopamine system. Voltammetric monitoring of dopamine signals in mouse
M Vasudevan et al.
Journal of pharmaceutical and biomedical analysis, 24(1), 25-31 (2000-12-07)
A simple, precise and accurate HPLC method was developed for the simultaneous estimation of phenyl-propanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrup. The method was carried out on a Shimpak C8 column with a mobile phase consisting of acetonitrile-triethylamine (pH
M A Lung et al.
Rhinology, 25(2), 95-100 (1987-06-01)
The effects of three commonly used H1 antihistamines on the nasal vascular and airway resistances were studied in the dog. Promethazine hydrochloride decreased nasal vascular resistance but increased nasal airway resistance in a dose-dependent manner. Diphenylpyraline hydrochloride in low doses
K O Ebete et al.
Journal of chromatography. B, Biomedical applications, 677(2), 319-323 (1996-03-03)
A rapid, reliable and specific reversed-phase high-performance liquid chromatographic procedure is described for the determination of diphenylpyraline hydrochloride at nanogram concentrations in plasma and urine. After extraction of the drug with n-pentane-2-propanol (50:1) from alkalinized samples, the organic extract was
Chika Hasegawa et al.
Rapid communications in mass spectrometry : RCM, 20(4), 537-543 (2006-01-19)
Ten antihistamine drugs, diphenhydramine, orphenadrine, chlorpheniramine, diphenylpyraline, triprolidine, promethazine, homochlorcyclizine, cyproheptadine, cloperastine and clemastine, have been found to be extractable from human plasma samples using MonoTip C18 tips, inside which C18- bonded monolithic silica gel was fixed. Human plasma (0.1
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