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Merck
  • An oral Mycobacterium bovis BCG vaccine for wildlife produced in the absence of animal-derived reagents.

An oral Mycobacterium bovis BCG vaccine for wildlife produced in the absence of animal-derived reagents.

Clinical and vaccine immunology : CVI (2009-07-03)
Martin L Cross, Matthew R Lambeth, Frank E Aldwell
ABSTRACT

Cultures of Mycobacterium bovis BCG, comprising predominantly single-cell bacilli, were prepared in broth without animal-derived reagents. When formulated into a vegetable-derived lipid matrix, the vaccine was stable in vitro and was immunogenic in vivo upon feeding it to mice. This formulation could be useful for oral vaccination of wildlife against tuberculosis, where concern over transmissible prions may preclude the field use of vaccines containing animal products.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
ECO TWEEN® 80, viscous liquid
Sigma-Aldrich
TWEEN® 80, BioXtra, viscous liquid
Sigma-Aldrich
TWEEN® 80, viscous liquid, Low-peroxide
Sigma-Aldrich
TWEEN® 80, from non-animal source
Sigma-Aldrich
TWEEN® 80, viscous liquid, Preservative Free, Low-peroxide; Low-carbonyls