- DNA methylation status correlates with adult β-cell regeneration capacity.
DNA methylation status correlates with adult β-cell regeneration capacity.
NPJ Regenerative medicine (2021-02-14)
Ishant Khurana, Keith Al-Hasani, Scott Maxwell, Harikrishnan K N, Jun Okabe, Mark E Cooper, Patrick Collombat, Assam El-Osta
PMID33580013
ABSTRACT
The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Anti-Neurogenin-3 Antibody, a.a. 80-93 of mouse Neurogenin-3., Chemicon®, from rabbit