Antibiotics
The use of antibiotics in cell cultures prevents contamination from pathogens that induce morphological or physiological changes in cell cultivation as well as contamination of cell lines. Antibiotics, such as penicillin, puromycin, and ampicillin, are molecules that specifically target and kill cells by inhibiting or regulating cell-wall synthesis, nucleic acid metabolism and protein synthesis, or disrupting membrane structure.
We offer a wide variety of effective antibiotics, antibiotic extraction kits, and antibiotic ready-made solutions in varying concentrations for reliable results in your lab. Our antibacterial, antiviral, antifungal, and antineoplastic agents control and eradicate cell culture contamination to maintain aseptic conditions in your lab. Moreover, certain antibiotics also function as selection agents to establish transfected/genetically modified cells depending on your research needs.
Selecting the right antibiotics for your cell contamination prevention, genetic marker selection and cell biology studies is driven by application information, activity spectrum, and usage data. Browse antibiotics by mechanism of action or by spectrum of activity.
| Antibiotics by Mechanism of Action | Antibiotics by Spectrum of Activity | |
Keeping your focus on creating breakthroughs, explore our full portfolio of reliable antibiotics below.
Related Articles
- Cell Culture Antibiotic Selection Guide
Cell culture antibiotic selection guide, including antibiotics for mammalian cell culture, plant cell culture, and antibiotic selection agents for cell culture.
- Antibiotics in Plant Tissue Culture Protocol
Reference guide and preparation guide for antibiotic and antimycotic use in plant tissue culture.
- Antibiotic Optimization for Cell Transduction Using a Cytotoxicity Profile
Experimentally determine the appropriate antibiotic concentration for selecting stable cell lines. This titration protocol can determine the lowest concentration of puromycin needed to efficiently select transduced cells.
- Why Use Antibiotics in Cell Culture?
Know when to use antibiotics to prevent bacterial or fungal, mycoplasma, or viral contamination in cell culture and find suitable antibiotics or other biological agents.
- Inhibition of Cell Wall Biosynthesis by Antibiotics
The specificity of β-lactam antibacterials is due to their ability to inhibit transpeptidase enzymes and prevent the assembly of the peptidoglycan layer in both Gram-positive and Gram-negative bacteria.
- Inhibition of Protein Synthesis by Antibiotics
Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere with the processes at the 30S subunit or 50S subunit of the 70S bacterial ribosome.
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