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B4184

Sigma-Aldrich

Brij® L23 solution

30 % (w/v) in H2O

Synonym(s):

Brij® 35 solution, C12E23, Polyoxyethylene (23) lauryl ether

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About This Item

CAS Number:
9002-92-0
MDL number:
MFCD00080891
UNSPSC Code:
12161900
PubChem Substance ID:
24891758
NACRES:
NA.25

biological source

synthetic

Quality Level

200

description

non-ionic

form

liquid

mol wt

~1198.0 g/mol

concentration

30 % (w/v) in H2O

aggregation number

40

CMC

91 μM

transition temp

cloud point ≥100 °C

solubility

water: soluble

density

1.024 g/mL

HLB

16.9

SMILES string

CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO

InChI

1S/C58H118O24/c1-2-3-4-5-6-7-8-9-10-11-13-60-15-17-62-19-21-64-23-25-66-27-29-68-31-33-70-35-37-72-39-41-74-43-45-76-47-49-78-51-53-80-55-57-82-58-56-81-54-52-79-50-48-77-46-44-75-42-40-73-38-36-71-34-32-69-30-28-67-26-24-65-22-20-63-18-16-61-14-12-59/h59H,2-58H2,1H3

InChI key

IEQAICDLOKRSRL-UHFFFAOYSA-N

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General description

Brij® L23, also known as Polyoxyethylene (23) lauryl ether, is an ethoxylated fatty alcohol derived from lauryl alcohol. It serves as a valuable non-ionic detergent widely utilized in biochemical studies. This versatile compound is particularly well-suited for protein solubilization and membrane protein isolation, making it a key component in various biochemical assays. Brij® L23′s non-ionic nature and unique properties also position it as an essential detergent for protein extraction and cell permeabilization, facilitating a broad spectrum of research in the same. Further, its use is instrumental in preserving the structural integrity and functionality of proteins, contributing significantly to studies involving proteins and their interactions in the area of biochemical research.

Application

Brij® L23 solution has been used:
  • as a supplement of De Man, Rogosa, Sharpe (MRS) broth for monitoring bacteriocin production by lactic acid bacteria(66)
  • as a component of developing buffer for the incubation of zymogram gel for metalloproteinase quantification(67)
  • as a component of activation buffer for recombinant human hepsin(68)

Biochem/physiol Actions

Brij® L23 solution is a surfactant and is used in the nanoparticle preparation by microemulsion method.

Features and Benefits

High-purity product ideal for biochemical research applications

Packaging

Some bottles may appear indented due to the packaging process. This does not affect product integrity or quality.

Preparation Note

In the event that material is in the gel phase at room temperature, the customer should heat the material to a temperature range of greater than 35°C and less than 60°C, and stir the solution for approximately 15 minutes before use.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Legal Information

Brij is a registered trademark of Croda International PLC

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H315,H319,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000276079
0000281714
0000287381
0000293842
0000296145

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Guillaume Morin et al.
Nutrients, 11(9) (2019-09-06)
Peroxides contaminating parenteral nutrition (PN) limit the use of methionine as a precursor of cysteine. Thus, PN causes a cysteine deficiency, characterized by low levels of glutathione, the main molecule used in peroxide detoxification, and limited growth in individuals receiving
Reverse microemulsion synthesis of CeO2 nanopowder using polyoxyethylene (23) lauryl ether as a surfactant
Pournajaf R, et al.
Ceramics International, 40(6), 8687-8692 (2014)
Darío Morais et al.
Rhinology, 50(1), 80-86 (2012-04-04)
Hereditary Haemorrhagic Telangiectasia or Rendu-Osler-Weber syndrome is a rare autosomal dominant vascular disease characterized by mucocutaneous and gastrointestinal telangiectases and localized arteriovenous malformations in lung, brain and liver. Epistaxis, due to rupture of telangiectases of the nasal mucosa, is the
N Shadid et al.
The British journal of surgery, 99(8), 1062-1070 (2012-05-26)
New minimally invasive treatment modalities, such as ultrasound-guided foam sclerotherapy (UGFS), are becoming more popular. In a multicentre randomized controlled non-inferiority trial, the effectiveness and costs of UGFS and surgery for treatment of the incompetent great saphenous vein (GSV) were
B McAree et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 43(6), 721-725 (2012-04-18)
To compare the half-life of STD and polidocanol air-based foams and the damage they inflict upon human great saphenous vein in an in-vitro model. The time for the volume of 3% STD and polidocanol foams to reduce by 10% (T(90))
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Enzymatic Assay of Cathepsin B

Cathepsin B is a lysosomal cysteine proteinase with broad specificity. This protocol uses Nα–CBZ–Arg–Arg–7–amido–4–methylcoumarin as the substrate for fluorometric detection of Cathepsin B activity.

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