700125P

DMHCA

Avanti Research^™ - A Croda Brand 700125P, powder

• Synonym(s): N,N-dimethyl-3β-hydroxycholenamide
• Empirical Formula (Hill Notation): C₂₆H₄₃NO₂
• CAS Number: 79066-03-8
• Molecular Weight: 401.63
• MDL number: MFCD11109453
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 5 mg (700125P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 700125P
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

N,N-dimethyl-3β-hydroxy-cholenamide (DMHCA) is a potent steroidal liver X receptor (LXR) ligand in vitro and in vivo. It is used to treat atherosclerosis.

N,N-dimethyl-3β-hydroxycholenamide (DHMCA) is a synthetic ligand for liver X receptor (LXR).

Application

DMHCA has been used as LXR activator to treat retinal endothelial cells in order to activate the sirtuin 1- liver X receptors (SIRT1-LXR) pathway.

It may be used as 3β-hydroxysterol-Δ²⁴-reductase (DHCR24) inhibitor.

Biochem/physiol Actions

N,N-dimethyl-3β-hydroxycholenamide (DHMCA) halts cholesterol biosynthesis by inhibiting 3β-hydroxysterol-Δ²⁴-reductase (DHCR24) enzyme. It may serve as a therapeutic agent for treating atherosclerosis, age-related macular degeneration and diabetic retinopathy.

DMHCA (N,N-dimethyl-3β-hydroxycholenamide) is a synthetic oxysterol and is an agonist for liver X receptors (LXR). It promotes cholesterol transport, expression of adenosine triphosphate (ATP) binding cassette transporters. DMHCA suppresses the proinflammatory cytokines stimulation, induced by oxysterol.

Packaging

5 mL Amber Glass Screw Cap Vial (700125P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids