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Merck

ZBTB33

zinc finger and BTB domain containing 33

Synonyms:
ZNF-kaiso, ZNF348
Species:
Human ZBTB33 (10009), Mouse Zbtb33 (56805), Rat Zbtb33 (501506), Zebrafish zbtb33 (562507), Horse ZBTB33 (100062002), domestic cat ZBTB33 (101086378), dog ZBTB33 (100685062), chicken ZBTB33 (422367), cow ZBTB33 (784871), sheep ZBTB33 (101112197) ...More
UniProtKB ID:
Q86T24, B2R5U6, O00319, Q7Z361, Q8IVP6, Q8N3P0
Gene ID:
  • Human(10009) Summary: This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]
  • Mouse(56805) zinc finger and BTB domain containing 33
  • Rat(501506) zinc finger and BTB domain containing 33
  • Zebrafish(562507) zinc finger and BTB domain containing 33
  • Horse(100062002) zinc finger and BTB domain containing 33
  • domestic cat(101086378) zinc finger and BTB domain containing 33
  • dog(100685062) zinc finger and BTB domain containing 33
  • chicken(422367) zinc finger and BTB domain containing 33
  • cow(784871) zinc finger and BTB domain containing 33
  • sheep(101112197) zinc finger and BTB domain containing 33
  • naked mole-rat(101708806) zinc finger and BTB domain containing 33
  • Domestic Rabbit(100348939) zinc finger and BTB domain containing 33
  • domestic guinea pig(100713178) zinc finger and BTB domain containing 33

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Antibodies

Product Number
Description
Species Reactivity
Application
HPA000755
Anti-ZBTB33 antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
HPA005732
Anti-ZBTB33 antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
SAB1404770
Monoclonal Anti-ZBTB33, (C-terminal) antibody produced in mouse, clone 2B2, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
AV38864
Anti-ZBTB33 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, rat
Application
western blot
WH0010009M1
Monoclonal Anti-ZBTB33 antibody produced in mouse, clone 2B2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot

esiRNA

Product Number
Description
Species
EHU038261
MISSION® esiRNA, targeting human ZBTB33,
Species
human
EMU014281
MISSION® esiRNA, targeting mouse Zbtb33,
Species
mouse