WWOX
WW domain containing oxidoreductase
Synonyms:
D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1
Species:
Human WWOX (51741), Mouse Wwox (80707), Rat Wwox (292041), fruit fly Wwox (34090), chicken WWOX (415801), Zebrafish wwox (393887), Horse WWOX (100055545), domestic cat WWOX (101093411), dog WWOX (610120), domestic guinea pig Wwox (100722863) ...More
UniProtKB ID:
Gene ID:
- Human(51741) Summary: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(80707) WW domain-containing oxidoreductase
- Rat(292041) WW domain-containing oxidoreductase
- fruit fly(34090) WW domain containing oxidoreductase
- chicken(415801) WW domain containing oxidoreductase
- Zebrafish(393887) WW domain containing oxidoreductase
- Horse(100055545) WW domain containing oxidoreductase
- domestic cat(101093411) WW domain containing oxidoreductase
- dog(610120) WW domain containing oxidoreductase
- domestic guinea pig(100722863) WW domain containing oxidoreductase
- naked mole-rat(101698327) WW domain containing oxidoreductase
- Domestic Rabbit(100353596) WW domain containing oxidoreductase
- cow(618792) WW domain containing oxidoreductase
- sheep(101120431) WW domain containing oxidoreductase
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-WWOX antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-WWOX antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-WWOX Antibody, clone 12G5, clone 12G5, from rat,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot
Anti-WWOX, N-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
western blot
western blot
Anti-phospho-WWOX (pTyr33) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot