TEK
TEK tyrosine kinase, endothelial
Synonyms:
CD202B, TIE-2, TIE2, VMCM, VMCM1
Species:
Human TEK (7010), Mouse Tek (21687), Rat Tek (89804), Zebrafish tek (30747), dog TEK (403714), domestic cat TEK (101091977), chicken TEK (427368), cow TEK (280939), domestic guinea pig Tek (100713324), naked mole-rat Tek (101710501)
UniProtKB ID:
Gene ID:
- Human(7010) Summary: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008]
- Mouse(21687) endothelial-specific receptor tyrosine kinase
- Rat(89804) TEK tyrosine kinase, endothelial
- Zebrafish(30747) TEK tyrosine kinase, endothelial
- dog(403714) TEK tyrosine kinase, endothelial
- domestic cat(101091977) TEK tyrosine kinase, endothelial
- chicken(427368) TEK tyrosine kinase, endothelial
- cow(280939) TEK tyrosine kinase, endothelial
- domestic guinea pig(100713324) TEK tyrosine kinase, endothelial
- naked mole-rat(101710501) TEK tyrosine kinase, endothelial
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ELISA
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-TEK antibody produced in mouse, clone 1A4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-Tie2/TEK Antibody, clone Ab33, clone Ab33, Upstate®, from mouse,
Species Reactivity
human, mouse, pig, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-phospho TIE2/TEK Antibody (Tyr992), 0.25 mg/mL, from rabbit,
Species Reactivity
bovine, human, mouse, rat, zebrafish
Application
immunoprecipitation (IP)
inhibition assay
western blot
inhibition assay
western blot
Anti-TIE2, C-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
immunohistochemistry
Anti-Phospho-TEK-pY1113 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
dot blot
dot blot
Small Molecule - Inhibitor
Product Number
Description
Species
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine, ≥98% (HPLC),
Species
human
Proteins
Product Number
Description
Species
TIE2 (771-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human