SIRT1
sirtuin 1
Synonyms:
SIR2L1
Species:
Human SIRT1 (23411), Mouse Sirt1 (93759), Rat Sirt1 (309757), domestic guinea pig Sirt1 (100717014), naked mole-rat Sirt1 (101720282), Domestic Rabbit SIRT1 (100349271), cow SIRT1 (613629), sheep SIRT1 (101102956), Zebrafish sirt1 (797132), chicken SIRT1 (423646) ...More
UniProtKB ID:
Gene ID:
- Human(23411) Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
- Mouse(93759) sirtuin 1
- Rat(309757) sirtuin 1
- domestic guinea pig(100717014) sirtuin 1
- naked mole-rat(101720282) sirtuin 1
- Domestic Rabbit(100349271) sirtuin 1
- cow(613629) sirtuin 1
- sheep(101102956) sirtuin 1
- Zebrafish(797132) sirtuin (silent mating type information regulation 2 homolog) 1
- chicken(423646) sirtuin 1
- dog(489012) sirtuin 1
- domestic cat(101087610) sirtuin 1
- Horse(100072571) sirtuin 1
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Small Molecule - Activator
Product Number
Description
Species
Activity Assay
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SIRT1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-SIRT1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-SIRT1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Sirt1 (Sir2) Antibody, Alexa Fluor™ 488 Conjugate, from rabbit, ALEXA FLUOR™ 488,
Species Reactivity
human, mouse
Application
immunocytochemistry
Anti-SIRT1 Antibody, clone 10E4, clone 10-E-4, from mouse,
Species Reactivity
human, mouse
Application
ChIP
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
SIRT1 human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
SIRT1, active, His tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human