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Merck

CACNA2D3

calcium channel, voltage-dependent, alpha 2/delta subunit 3

Synonyms:
HSA272268
Species:
UniProtKB ID:
Gene ID:
  • Human(55799) Summary: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • Mouse(12294) calcium channel, voltage-dependent, alpha2/delta subunit 3
  • Rat(306243) calcium channel, voltage-dependent, alpha2/delta subunit 3
  • naked mole-rat(101712827) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • domestic guinea pig(100724165) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • sheep(101105365) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • Zebrafish(100535196) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • cow(519644) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • Horse(100059197) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • domestic cat(101094658) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • dog(476585) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • chicken(415996) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • Zebrafish(100148645) calcium channel, voltage dependent, alpha2/delta subunit 3

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
Gabapentin, United States Pharmacopeia (USP) Reference Standard,
Species
human
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin, solid,
Species
human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
ANTI-CACNA2D3 (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
western blot

Small Molecule - Blocker

Product Number
Description
Species
Bepridil hydrochloride, powder,
Species
human
Terodiline hydrochloride, ≥98% (HPLC), solid,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CACNA2D3,
Species
human