T2386

Δ⁹-Tetrahydrocannabinol solution

ethanol solution

• Synonym(s): Δ¹-Tetrahydrocannabinol
• Empirical Formula (Hill Notation): C₂₁H₃₀O₂
• CAS Number: 1972-08-3
• Molecular Weight: 314.46
• MDL number: MFCD00083207
• UNSPSC Code: 12352200
• PubChem Substance ID: 24900035
• NACRES: NA.77

Properties

• form: ethanol solution
• Quality Level: 200
• drug control: USDEA Schedule I; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)
• concentration: 25 mg/mL (+/- 5%)
• storage temp.: −20°C
• SMILES string: [H][C@@]12CCC(C)=C[C@@]1([H])c3c(O)cc(CCCCC)cc3OC2(C)C
• InChI: 1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1
• InChI key: CYQFCXCEBYINGO-IAGOWNOFSA-N
• Gene Information: human ... CNR1(1268) , CNR2(1269) ; mouse ... Cnr1(12801) ; rat ... Cnr1(25248)

Description

Application

Δ9-tetrahydrocannabinol solution has been used to study its effects on schizophrenia-related behaviors in a developmental mouse model of schizophrenia.

Biochem/physiol Actions

Δ⁹-Tetrahydrocannabinol or Δ⁹-THC is a psychoactive ingredient in marijuana that is known to function as a neuroprotective antioxidant²¹. In vivo microdialysis studies have reported that Δ⁹-THC can enhance extracellular dopamine efflux in the nucleus accumbens of conscious, freely-moving rats²².

Agonist at CB₁ and CB₂ cannabinoid receptors. Hallucinogen; major psychoactive component of marijuana from Cannabis sativa.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Δ⁹-Tetrahydrocannabinol solution is essentially insoluble in water.

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H319
• Precautionary Statements: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 57.2 °F
• Flash Point(C): 14 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves