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Key Documents

SML3487

Sigma-Aldrich

X4-2

≥98% (HPLC)

Synonym(s):

(Cycloheptanecarbonyl)-L-phenylalanine, N -(Cycloheptylcarbonyl)-L-phenylalanine

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About This Item

Empirical Formula (Hill Notation):
C17H23NO3
CAS Number:
Molecular Weight:
289.37
UNSPSC Code:
12352200

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

Biochem/physiol Actions

X4-2 is an inactive control probe for MS47134, which is a selective agonist probe of the GPCR orphan receptor MRGPRX4.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Can Cao et al.
Nature, 600(7887), 170-175 (2021-11-19)
The MRGPRX family of receptors (MRGPRX1-4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently1. Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-mediated hypersensitivity reactions2-5. MRGPRX2 couples to

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