S7882

(−)-Scopolamine N-butyl bromide

≥98% (TLC), powder

• Synonym(s): (−)-N-Butylscopolamine bromide, Hyoscine N-butyl bromide
• Empirical Formula (Hill Notation): C₂₁H₃₀BrNO₄
• CAS Number: 149-64-4
• Molecular Weight: 440.37
• EC Number: 205-744-1
• MDL number: MFCD00078561
• UNSPSC Code: 12352116
• PubChem Substance ID: 24277872
• NACRES: NA.77

Properties

• Assay: ≥98% (TLC)
• form: powder
• optical activity: [α]25/D −20.8°, c = 3 in H₂O(lit.)
• color: white
• solubility: H₂O: 50 mg/mL
• SMILES string: [Br-].[H][C@@]12C[C@H](C[C@@]([H])([C@]3([H])O[C@]13[H])[N+]2(C)CCCC)OC(=O)[C@H](CO)c4ccccc4
• InChI: 1S/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15-,16-,17-,18+,19-,20+,22?;/m1./s1
• InChI key: HOZOZZFCZRXYEK-GSWUYBTGSA-M
• Gene Information: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

Description

Application

(−)-Scopolamine N-butyl bromide was used as standard in designing a procedure for quantification of compounds using CE-MS.⁸

Biochem/physiol Actions

Competitive muscarinic acetylcholine receptor antagonist; antispasmodic.

Scopolamine is an anti-muscarinic and cholinolytic alkaloid that inhibits parasympathetic-cholinergic system.⁵ The central effects include hallucinations, disorientation, restlessness and euphoria.⁶ Scopolamine disturb the stimulus detection performance in rats by interfering with the reticular cholinergic pathways.⁷

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 + H332
• Precautionary Statements: P261 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves