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S4936

Sigma-Aldrich

Anti-Sodium Channel, Brain Type I (α subunit) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-BI, Anti-SP11I, Anti-Scna1

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About This Item

MDL number:
MFCD02097410
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat, mouse

technique(s)

immunohistochemistry: suitable using rat brain section
western blot: 1:200 using rat brain membranes

UniProt accession no.

P04774

storage temp.

−20°C

Gene Information

mouse ... Scn1a(20265)
rat ... Scn1a(81574)

Immunogen

synthetic peptide corresponding to amino acids 465-481 of the α subunit of rat type I voltage-gated sodium channel (VGSC, SP11I) with additional N-terminal lysine and tyrosine, conjugated to KLH. The epitope corresponds to the sequence in the intracellular loop between the I and II domains of type I VGSC α subunit. Homology with human is identical.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312,H412

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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D Gordon et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(23), 8682-8686 (1987-12-01)
Anti-peptide antibodies that distinguish between the rat brain sodium channel subtypes referred to as RI and RII were prepared and used to determine their relative expression in nerve and muscle tissues. Sodium channels purified from rat brain are approximately 18%
R E Westenbroek et al.
Neuron, 3(6), 695-704 (1989-12-01)
Immunocytochemical localization of Na+ channel subtypes RI and RII showed that RI immunoreactivity is relatively low and homogeneous along the rostral-caudal extent of sagittal brain sections, whereas RII staining is heterogeneous and relatively dense in the forebrain, substantia nigra, hippocampus
M Noda et al.
Nature, 322(6082), 826-828 (1986-08-03)
The voltage-gated sodium channel is a transmembrane protein essential for the generation of action potentials in excitable cells. It has been reported that sodium channels purified from the electric organ of the electric eel, Electrophorus electricus, and from chick cardiac
R E Westenbroek et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 12(6), 2259-2267 (1992-06-01)
Type I and type III Na+ channels are localized mainly in neuronal cell bodies in mouse brain. Type II channels are preferentially localized in unmyelinated fiber tracts but are not detectable in normally myelinated fibers. In shiverer mice, which lack

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