P9497
Anti-Potassium Channel hKv11.1 antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-Ether-a-go-go-related Channel, Anti-HERG
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
western blot: 1:400 using the lysate of HEK 293 cells, stably expressing HERG
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KCNH2(3757)
mouse ... Kcnh2(16511)
rat ... Kcnh2(117018)
Immunogen
GST fusion protein with sequence corresponding to residues 1106-1159 of human KV11.1. The sequence is identical in rabbit and has 51/54, 50/54, and 50/54 residues identical in dog, mouse, and rat. Homology with related proteins: rat erg2 is 22/54 residues identical and rat erg3 is 21/54 residues identical.
Physical form
Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.025% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Clayton Whitmore et al.
Skeletal muscle, 10(1), 1-1 (2020-01-18)
Skeletal muscle atrophy is the net loss of muscle mass that results from an imbalance in protein synthesis and protein degradation. It occurs in response to several stimuli including disease, injury, starvation, and normal aging. Currently, there is no truly
J S Mitcheson et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(22), 12329-12333 (2000-09-27)
Mutations in the HERG K(+) channel gene cause inherited long QT syndrome (LQT), a disorder of cardiac repolarization that predisposes affected individuals to lethal arrhythmias [Curran, M. E. , Splawski, I., Timothy, K. W., Vincent, G. M., Green, E. D.
J I Vandenberg et al.
Trends in pharmacological sciences, 22(5), 240-246 (2001-05-08)
The K+ channel encoded by the human ether-à-go-go related gene (HERG) is one of many ion channels that are crucial for normal action potential repolarization in cardiac myocytes. HERG encodes the pore-forming subunit of the rapid component of the delayed
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