Skip to Content
Merck
All Photos(1)

Key Documents

GE17-5481-02

Capto™ Core 700

Cytiva 17-5481-02, pack of 100 mL

Synonym(s):

Capto Core 700 Resin

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
23151817
NACRES:
NA.56

ligand

octylamine

packaging

pack of 100 mL

manufacturer/tradename

Cytiva 17-5481-02

matrix

highly cross-linked agarose

avg. part. size

75 (d₅₀v is the median particle size of the cumulative volume distribution)

cleaning in place

3-13(pH interval where the medium can be subjected to, for cleaning- or sanitization-in-place.)

working range

2-14(pH interval where the medium can be operated without significant change in function.)

capacity

~13 mg binding capacity (ovalbumin)

suitability

suitable for bioprocess medium

General description

Capto™ Core 700 exhibits dual functionality due to the novel core bead technology and multimodal, octylamine ligand. This chromatography resin possesses size exclusion and binding properties. Capto™ Core 700 comprises a ligand-activated core and inactive shell. The inactive shell aids in preventing large molecules (cut off ~ Mr 700 000) from entering the core via the pores of the shell. The core of each bead is functionalized with hydrophobic and positively charged ligands. The smaller size impurities bind to the multimodal internalized ligands and the larger molecules get collected in the column flowthrough. Cleaning-in-place (CIP) processes use NaOH and, in most cases, a solvent to remove bound contaminants from the beads. HiTrap® and HiScreen™ columns can be linked in series for enhanced capacity, making them ideal for generating an efficient and robust separation system.
Dynamic binding capacities were measured at 10% breakthrough with a residence time of 3 min (1.6 ml/min = 200 cm/h) in HiScreen columns. Buffer: 20 mM Tris-HCl, 150 mM NaCl, pH 7.5.

Features and Benefits

  • This novel core bead technology enables efficient contaminant capture while target molecules get trapped in the flowthrough.
  • Hydrophobic and positively charged ligands
  • Offers improved productivity and higher flow rates than standard size exclusion (gel filtration) methods.
  • Flowthrough chromatography allows straightforward and robust performance.
  • Multimodal removal of contaminants
  • Convenient small-scale purification and process development
  • Scaling up is simple using prepacked HiTrap® and HiScreen™ columns.
  • Resin meets industrial demands for supply security and regulatory support.

Storage and Stability

Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
Store at 4 to 30 °C (20% Ethanol)

Analysis Note

To view the Certificate of Analysis for this product, please visit www.cytiva.com.

Legal Information

Capto is a trademark of Cytiva
HiScreen is a trademark of Cytiva
HiTrap is a registered trademark of Cytiva

Pictograms

Flame
GHS02

Signal Word

Warning

Hazard Statements

H226

Storage Class Code

3 - Flammable liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Maintenance of Multimodal Chromatography Media and Storage Conditions

This page describes the maintenance of media and storage conditions for multimodal chromatography using GE Healthcare products.

Protocols

Capto Core 700

Capto Core 700 from GE Healthcare is designed for intermediate purification and polishing of viruses and other large biomolecules in flowthrough mode.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service