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Key Documents

E1904

Sigma-Aldrich

Ethyl-3,4-dephostatin

>99% (HPLC), solid

Synonym(s):

3,4-Dihydroxy-N-ethyl-N-nitrosoaniline

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About This Item

Empirical Formula (Hill Notation):
C8H10N2O3
CAS Number:
Molecular Weight:
182.18
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Assay

>99% (HPLC)

form

solid

color

brown

solubility

DMSO: soluble 22 mg/mL
H2O: soluble 8 mg/mL

storage temp.

2-8°C

SMILES string

CCN(N=O)c1ccc(O)c(O)c1

InChI

1S/C8H10N2O3/c1-2-10(9-13)6-3-4-7(11)8(12)5-6/h3-5,11-12H,2H2,1H3

InChI key

ZTXUSFPBLYQDDN-UHFFFAOYSA-N

Biochem/physiol Actions

Stable analog of dephostatin. Selective inhibitor of protein tyrosine phosphatase 1B and SHPTP-1. Does not inhibit CD45-associated phosphatases.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Store under nitrogen

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J H Kim et al.
Cell death & disease, 4, e588-e588 (2013-04-13)
Hypoxia enhances the proliferation and migration of adipose-derived stem cells (ASCs) via the generation of reactive oxygen species (ROS). Therefore, this study primarily investigated whether or not ROS generation could regulate microRNA-210 (miR-210) expression, and increase proliferation/migration of ASCs. In

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