SMB00953

2-Cyano-3,3-diphenylacrylic acid

≥95%

• Synonym(s): α-Cyano-β-diphenylacrylic acid, 2-Cyano-3,3-diphenylpropenoic acid
• Empirical Formula (Hill Notation): C₁₆H₁₁NO₂
• CAS Number: 10380-41-3
• Molecular Weight: 249.26
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• biological source: synthetic
• Quality Level: 200
• Assay: ≥95%
• form: solid
• mol wt: 249.26 g/mol
• storage condition: (Tightly closed. Dry.)
• technique(s): HPLC: suitable
• color: white to off-white
• storage temp.: 2-8°C
• InChI: 1S/C16H11NO2/c17-11-14(16(18)19)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10H,(H,18,19)
• InChI key: VSXIZXFGQGKZQG-UHFFFAOYSA-N

Description

General description

2-Cyano-3,3-diphenylacrylic acid (CDA) belongs to the class of α,β-unsaturated carboxylic acids. It is a primary metabolite of Octocrylene, an organic sunscreen that functions by absorbing UVB radiation and short UVA wavelengths, commonly utilized in cosmetics for sun protection. CDA exhibits prolonged systemic availability after dermal exposure which may accumulate in the body. It can be used to study skin-permeable selective cyclooxygenaswe-2 inhibitor composition, and to study hydrophilic components of cosmetic compositions, such as in sunscreen.

Application

2-Cyano-.3-diphenylacrylic acid finds application in metabolomics, cosmetics and cancer research

Biochem/physiol Actions

Within the human body, Octocrylene, a non-polar compound, undergoes metabolism to become a water-soluble metabolite 2-cyano-3,3-diphenylacrylic acid, which is excreted through the kidneys. A pilot study in the general population has consistently detected CDAA, and its levels have been linked to recent sunscreen application.

Features and Benefits

• High quality compound suitable for multiple research applications
• Compatible with a wide variety of chromatographic and spectrometry techniques

Other Notes

For additional information on our range of Biochemicals, please complete this form.

This product is intended for research purposes only, and it is not meant for human consumption.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable