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M4125

Sigma-Aldrich

D-Mannitol

≥98% (GC)

Synonym(s):

Mannite

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About This Item

Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
Beilstein:
1721898
EC Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.21

biological source

plant

Quality Level

Assay

≥98% (GC)

form

powder

color

white

useful pH range

5.0-6.5 (25 °C, 182 g/L, (77 °F ))

mp

167-170 °C (lit.)

solubility

water: 100 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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General description

D-Mannitol, a naturally occurring six-carbon sugar alcohol or polyol, is found in plants such as algae, onions, grasses, and olives. It is considered safe due to its relatively lower glycemic index than sucrose.

Application

D-Mannitol has been used:
  • in osmotic loading to adjust the osmolarity of solutions
  • as a component of test sugar solution for cellobiose-mannitol permeability test
  • as an internal standard in nuclear magnetic resonance (NMR) to compare/analyze the mannitol concentrations in urine samples
  • to treat the control cells and regulate the osmotic pressure of high glucose

D-mannitol has been used as a hydroxyl radical scavenger and as a medium supplement.

Biochem/physiol Actions

D-Mannitol may play an important role in lipolysis and fat oxidation as it can enhance the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase 1 (ACC). It serves as an anti-obesity supplement. D-Mannitol stimulates the synthesis of short-chain fatty acids (SCFAs), which regulate lipid metabolism in the liver.
A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Other Notes

To gain a comprehensive understanding of our extensive range of Sugar alcohols for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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