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NXF-20

Millipore

Natrix® Q Process 150

Synonym(s):

Natrix® Q Membrane Adsorber

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About This Item

UNSPSC Code:
41115711
eCl@ss:
32011308

ligand

quaternary amine

Quality Level

400

description

Natrix® Q Process 150

product line

Natrix®

parameter

0.6-3 L/min flow rate

bed H

0.5 mm

bed volume

115 mL

matrix active group

Macroporous polymer

pore size

0.4 μm pore size

capacity

23 g binding capacity (BSA)(per device

per device)

separation technique

strong anion exchange

shipped in

ambient

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General description

Strong anion exchange chromatography membrane design to purify biomolecules with a high density of quaternary amine ligand the enables fast flow rates and high throughput at high loads while maintaining excellent impurity reduction
With a revolutionary three-dimensional macroporous hydrogel structure that provides a high density of binding sites and rapid mass transfer, Natrix®chromatography membranes deliver binding capacity that exceeds resin-based columns with fast flow rates typical of traditional membrane adsorbers. This combination of performance and speed in a single-use, plug-and-play device format enables low-risk, scalable solutions for efficient biomolecule purification

Natrix® Q chromatography membrane is a high productivity strong anion exchange membrane designed for biomolecule purification. The unique Natrix® Q chromatography membrane is a porous polyacrylamide hydrogel containing a high density of pendant quaternary ammonium (Q) binding groups that are directly polymerized within the an inert, macroporous membrane scaffold. The interconnected pore structure and high functional group density enables fast flow rates (seconds of residence time) with impressive throughput to extremely high loads while maintaining excellent impurity reduction across a wide range of buffer conditions. The Natrix® Q chromatography membrane design delivers improvements in productivity, flexibility, and process robustness and economics for any bioprocess design. The Natrix® Q Process 150 is process scale device designed for full-scale clinical and commercial manufacturing.

mAb nominal polishing capacity: 1150 g
Membrane configuration: Pleated

1 device per package

Features and Benefits

Natrix® Q membrane adsorber provides users with:

  • High density of quaternary amine binding sites enabling rapid mass transfer
  • High binding capacity even at fast flow rates
  • Combination of performance and speed in, single use, plug-and-play device format enables low risk, scalable solutions for efficient biomolecule purification.

Packaging

Double bagged

Legal Information

NATRIFLO is a trademark of Merck KGaA, Darmstadt, Germany
NATRIX is a registered trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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Renaud Jacquemart et al.
Computational and structural biotechnology journal, 14, 309-318 (2016-08-30)
The current processing paradigm of large manufacturing facilities dedicated to single product production is no longer an effective approach for best manufacturing practices. Increasing competition for new indications and the launch of biosimilars for the monoclonal antibody market have put
Mochao Zhao et al.
Vaccine, 37(36), 5491-5503 (2018-04-09)
Affinity chromatography is among the most powerful separation techniques, achieving the finest separation with high yields even in the most challenging feed streams. Incorporating affinity chromatography in vaccine purification has long been attempted by researchers to improve unit yield and
Ying Hou et al.
Biotechnology progress, 31(4), 974-982 (2015-05-29)
Protein A chromatography is widely employed for the capture and purification of monoclonal antibodies (mAbs). Because of the high cost of protein A resins, there is a significant economic driving force to seek new downstream processing strategies. Membrane chromatography has

Articles

Robust, load independent viral clearance in monoclonal antibody purification with Natrix® Q chromatography membrane

Membrane adsorbers are a cost-effective, robust, single-use solution for monoclonal antibody polishing

Comparison of Process-related Impurity Clearance for Membrane Adsorbers and Resin-based Chromatography Technologies

The performance of membrane adsorbers for antibody purification is compared to quaternary amine resins, membranes, and salt-tolerant primary amine membranes.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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