8.52324

Fmoc-bishomopropargylglycine

Novabiochem^®

• Synonym(s): Fmoc-bishomopropargylglycine
• Empirical Formula (Hill Notation): C₂₂H₂₁NO₄
• Molecular Weight: 363.41
• UNSPSC Code: 12352209

Properties

• Quality Level: 200
• product line: Novabiochem^®
• form: solid
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: acetylene
• storage temp.: 15-25°C

Description

General description

Building block for the introduction by Fmoc SPPS of an amino acid bearing an alkyne side chain. Such derivatives are useful tools for the synthesis of cyclic peptides by an alkyne-alkyne Glaser coupling, involving Cu(OAc)₂/pyridine and heating to 60 °C using microwaves.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable