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Key Documents

8.01663

Sigma-Aldrich

Boron trifluoride-methanol complex

(20% solution in methanol) for synthesis

Synonym(s):

BF3 methanol

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About This Item

UNSPSC Code:
12352301
NACRES:
NA.22

vapor pressure

4 hPa ( 20 °C)

Quality Level

200

form

liquid

autoignition temp.

420 °C

expl. lim.

5.5 % (v/v) Methanol)

transition temp

flash point 16 °C

density

0.89 g/cm3 at 20 °C

storage temp.

2-30°C

General description

Boron trifluoride-methanol complex (BF-M) is Lewis acid boron trifluoride incoordination with methanol. BF-M is a powerful acidic catalyst for the esterification of fatty acids. In the deacetylation of acetanilides, the complex displayed excellent deprotection selectivity against amino-protecting groups.

Application

Boron trifluoride-methanol complex is used:
  • As a reagent for deprotection of N-acetyl derivatives (acetylated amines of cyanine-type dyes).
  • As a starting material in the automated radiosynthesis procedure for [18F]tetrafluoroborate.

Analysis Note

Assay BF3 (acidimetric): 14.0 - 16.0 %
Density (d 20 °C/ 4 °C): 0.880 - 0.895

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

60.8 °F

Flash Point(C)

16 °C

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificates of Analysis (COA)

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Boron trifluoride--methanol complex-mild and powerful reagent for deprotection of labile acetylated amines
Miltsov S, et al.
Tetrahedron Letters, 44(11), 2301-2303 (2003)

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