5.00554
MHY1485
≥97% (HPLC), solid, mTOR activator, Calbiochem®
Synonym(s):
mTOR Activator, MHY1485, 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine, Autophagy Inhibitor III
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About This Item
Empirical Formula (Hill Notation):
C17H21N7O4
CAS Number:
Molecular Weight:
387.39
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Product Name
mTOR Activator, MHY1485,
Assay
≥97% (HPLC)
Quality Level
form
solid
potency
~2 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
pale yellow
solubility
DMSO: 12.5 mg/mL
storage temp.
2-8°C
General description
MHY1485, a small-molecule activator of the mammalian target of rapamycin (mTOR), exerts an inhibitory effect on the autophagic process by preventing the fusion between autophagosomes and lysosomes, resulting in the accumulation of LC3II protein and the enlargement of autophagosomes. It can also protect osteoblasts from dexamethasone-induced damage by inhibiting the mitochondrial death pathway provoked by dexamethasone.
Application
mTOR Activator, MHY1485 has been used to activate the mammalian target of rapamycin (mTOR) pathway in mice with Parkinson disease (PD) to reverse the effects of tumor necrosis factor α–induced protein 3 (TNFAIP3) on the mitigation of injury in mice and in SK-N-SH cells induced with 1-Methyl-4-phenylpyridinium (MPP+).
Biochem/physiol Actions
Cell permeable: yes
Reversible: yes
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Choi, Y. J., et al. 2012. PLoS. One.7, e43418.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Yeon Ja Choi et al.
PloS one, 7(8), e43418-e43418 (2012-08-29)
Autophagy is a major degradative process responsible for the disposal of cytoplasmic proteins and dysfunctional organelles via the lysosomal pathway. During the autophagic process, cells form double-membraned vesicles called autophagosomes that sequester disposable materials in the cytoplasm and finally fuse
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