454586

NMDAR2C/2D Inhibitor, DQP-1105

The NMDAR2C/2D Inhibitor, DQP-1105 controls the biological activity of NMDAR2C/2D. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonym(s): NMDAR2C/2D Inhibitor, DQP-1105, NMDA Antagonist IV, DQP-1105
• Empirical Formula (Hill Notation): C₂₉H₂₄BrN₃O₄
• CAS Number: 380560-89-4
• Molecular Weight: 558.42
• MDL number: MFCD02989065
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow-white
• solubility: DMSO: 10 mg/mL, pale yellow
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C(O)CCC(N1N=C(C2=C(C3=CC=CC=C3)C4=C(NC2=O)C=CC(C)=C4)CC1C5=CC=C(Br)C=C5)=O

Description

General description

A dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC₅₀ = 5.4 µM) and GluN1/GluN2D (2.2 µM) over GluN1/GluN2B (206 µM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC₅₀ values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine.

Packaging

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Other Notes

Acker, T., et al. 2011. Mol. Pharmacol.80, 782.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable