444896

MAS 7

A cell-permeable, amphiphilic, mastoparan analog with five-fold greater potency than Mastoparan.

• Synonym(s): MAS 7
• Empirical Formula (Hill Notation): C₆₇H₁₂₄N₁₈O₁₅
• CAS Number: 145854-59-7
• Molecular Weight: 1421.81
• MDL number: MFCD00144726
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: water: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C67H124N18O15/c1-18-38(12)53(71)67(100)85-51(32-52(70)86)66(99)84-50(31-37(10)11)64(97)79-45(24-20-22-26-69)61(94)75-42(16)58(91)82-47(28-34(4)5)62(95)76-39(13)55(88)73-40(14)57(90)81-48(29-35(6)7)63(96)77-41(15)56(89)78-44(23-19-21-25-68)60(93)74-43(17)59(92)83-49(30-36(8)9)65(98)80-46(54(72)87)27-33(2)3/h33-51,53H,18-32,68-69,71H2,1-17H3,(H2,70,86)(H2,72,87)(H,73,88)(H,74,93)(H,75,94)(H,76,95)(H,77,96)(H,78,89)(H,79,97)(H,80,98)(H,81,90)(H,82,91)(H,83,92)(H,84,99)(H,85,100)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,53-/m0/s1
• InChI key: HOLQXBRPSSZJMZ-FGRXCANLSA-N

Description

General description

A cell-permeable, amphiphilic, mastoparan analog with five-fold greater potency than Mastoparan Cat. No. 444898. An activator of α-subunit of G-proteins. Evokes rapid upregulation of FAK tyrosine phosphorylation via activation of G-proteins.

Mastoparan analog with five-fold greater potency than mastoparan. An activator of the α-subunit of G -proteins. Evokes a rapid upregulation of FAK tyrosine phosphorylation via activation of G-proteins.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
α-subunit of G-proteins

Product does not compete with ATP.

Reversible: no

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Ala-Leu-Leu-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Mironov, S.L., and Richter, D.W. 2000. Brain Res.853, 60.
Park, H.S., et al. 2000. Biochim. Biophys. Acta1484, 151.
Zhang, C., et al. 1996. FEBS Lett. 386, 185.
Leyte, A., et al. 1992. EMBO J.11 4795.
Higashijima, T., et al. 1990. J. Biol. Chem.265, 14176.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable