936561

(S,R,S)-AHPC-CO-PEG1-C2-acid

≥95%

• Synonym(s): 3-(3-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl) pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propanoic acid, 3-[3-[[(S)-1-[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]propanoic acid
• Empirical Formula (Hill Notation): C₂₈H₃₈N₄O₇S
• CAS Number: 2172820-07-2
• Molecular Weight: 574.69
• MDL number: MFCD32903606
• UNSPSC Code: 12352106

Properties

• Quality Level: 100
• Assay: ≥95%
• form: powder or crystals
• color: white to light yellow
• storage temp.: 2-8°C
• SMILES string: C([C@@H](NC(CCOCCC(O)=O)=O)[C@@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

Description

Application

(S,R,S)-AHPC-CO-PEG1-C2-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation
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Features and Benefits

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable