933570
NanoFabTx™- Maleimide Lipid Mix
for synthesis of maleimide-functionalized liposomes
Synonym(s):
Cholesterol, DSPC-PEG-Maleimide, HSPC
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About This Item
UNSPSC Code:
12352211
NACRES:
NA.21
Quality Level
storage temp.
−20°C
Application
NanoFabTx™ Maleimide Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of maleimide-functionalized liposomes. Maleimide is a stable and easy-to-handle moiety that rapidly and covalently conjugates thiol groups of cysteine residues in proteins or peptides. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with maleimide groups using extrusion and microfluidics are also included. The synthesized maleimide-functionalized liposomes enable facile conjugation of targeting groups like proteins, peptides, and other thiol-containing moieties onto the liposome surface for targeted drug delivery.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with maleimide groups using extrusion and microfluidics are also included. The synthesized maleimide-functionalized liposomes enable facile conjugation of targeting groups like proteins, peptides, and other thiol-containing moieties onto the liposome surface for targeted drug delivery.
Features and Benefits
- A ready-to-use nanoformulation lipid blend for the synthesis of maleimide-functionalized liposomes
- Step-by-step protocols developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible liposomes
- Maleimide surface functionalization allows for targeting ligand and protein conjugation to enable targeted drug delivery
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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