924083

TAMRA-a-TCO

• Synonym(s): (R,E)-2-(6-(Dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl)-5-((5-(2-(1-hydroxycyclooct-4-en-1- yl)acetamido)pentyl)carba
• Empirical Formula (Hill Notation): C₄₀H₄₈N₄O₆
• Molecular Weight: 680.83

Properties

• reaction suitability: reaction type: click chemistry; reagent type: chemical modification reagent; reagent type: fluorescent-labelling reagent
• Quality Level: 100
• storage temp.: −20°C

Description

Application

TAMRA-a-TCO is an axial trans-cyclooctene (a-TCO) for bioconjugation and protein labeling. As demonstrated by the Joe Fox lab in Pigga, et al, a-TCOs are more hydrophilic and reactive than standard TCOs. The fluorescent TAMRA-a-TCO was developed for rapid, live-cell and in vivo experiments. It is cell permeable, reacts with tetrazines intracellularly via Diels-Alder chemistry, and exhibits reduced background fluorescence relative to other TAMRA TCO tags when imaged using fluorescence microscopy (illumination at λ=531 nm).

Other new a-TCOs:

• NHS ester-a-TCO (MKE211512)
• Alkyne-a-TCO (MKE211515)
• Amine-a-TCO (MKE211516)

Safety Information

• Storage Class Code: 11 - Combustible Solids