909432
Fluorinated VHL Spy Molecule 2
≥98%
Synonym(s):
(2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide, VHL reporter ligand
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About This Item
Empirical Formula (Hill Notation):
C14H14BrF3N2O3
CAS Number:
Molecular Weight:
395.17
UNSPSC Code:
12352101
ligand
VH032 derivative
Assay
≥98%
form
powder
SMILES string
O=C([C@@H]1C[C@@H](O)CN1C(C(F)(F)F)=O)NCC2=CC=C(Br)C=C2
Application
Fluorinated VHL Spy Molecule 2 can be used for the discovery of new von Hippel-Lindau (VHL) binders. Based on VH032 (cat# 901490), this reporter was designed in the lab of Alessio Ciulli to bind the hydroxyproline (Hyp) recognition site of VHL. When used in competition ligand-observed 19F NMR screening experiments, its displacement indicates binding by another molecule. Additional Fluorinated VHL Spy Molecules are available as listings 909459, 909440, and 909416.
The E3 ligase VHL is of growing interest for targeted protein degradation and these spy molecules will facilitate the identification of novel VHL ligands and VHL-based degraders.
The E3 ligase VHL is of growing interest for targeted protein degradation and these spy molecules will facilitate the identification of novel VHL ligands and VHL-based degraders.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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